Epidermolysis Bullosa (EB) is a group of rare genetic connective tissue disorders that is present in 1 out of every 20,000 live births in the United States. It causes the skin to be so fragile that the slightest friction can cause severe blistering – inside and outside the body. EB can occur in every racial and ethnic group, and affects both sexes equally. Severe forms of EB cause patients to live with constant pain and scarring. The worst forms of EB lead to eventual disfigurement, disability and often early death. There is no cure, and the research is on-going. Click to learn more.